HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylcarbodiimide → HCID 88531913, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylcarbodiimide | HCID 12734 | — |
| Reactant | N-[(2,4-dichloro-3-isothiocyanatophenyl)methyl]-2,2-dimethylpropanamide | HCID 56840192 | — |
| Reactant | HCID 86666472 | HCID 86666472 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 88531913 | HCID 88531913 | — |
Reaction Steps
The title compound is prepared in analogy to 6c from (R)—N-(4-trifluoromethoxyphenyl)-2-[3-fluoro-pyrrolidinyl]-4-(2,2-difluoro-ethylamino)-5-amino-benzoic acid amide (94 mg, 0.20 mmol), and N-(2,4-dichloro-3-isothiocyanato-benzyl)-2,2-dimethyl-propionamide (64 mg, 0.20 mmol), DIC (62 μL, 0.40 mmol) and THF (10 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08674113B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-52564f561d654ea2b3f946a72c49b406 |
| Source note | uspto-grants-2014_03 |