Diisopropylcarbodiimide → HCID 88531913, compound

HRID 1189661Notes

Reaction equation

HRID 1189661 reaction equation
[F:1][C:2]([F:32])([F:31])[O:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:30])[C:12]2[CH:17]=[C:16]([NH2:18])[C:15]([NH:19][CH2:20][CH:21]([F:23])[F:22])=[CH:14][C:13]=2[N:24]2[CH2:28][CH2:27][C@@H:26]([F:29])[CH2:25]2)=[CH:6][CH:5]=1.[Cl:33][C:34]1[C:47]([N:48]=[C:49]=S)=[C:46]([Cl:51])[CH:45]=[CH:44][C:35]=1[CH2:36][NH:37][C:38](=[O:43])[C:39]([CH3:42])([CH3:41])[CH3:40].CC(C)N=C=NC(C)C>C1COCC1>[F:32][C:2]([F:31])([F:1])[O:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([C:12]2[C:13]([N:24]3[CH2:28][CH2:27][C@@H:26]([F:29])[CH2:25]3)=[CH:14][C:15]3[N:19]([CH2:20][CH:21]([F:23])[F:22])[C:49]([NH:48][C:47]4[C:46]([Cl:51])=[CH:45][CH:44]=[C:35]([CH2:36][NH:37][C:38](=[O:43])[C:39]([CH3:40])([CH3:41])[CH3:42])[C:34]=4[Cl:33])=[N:18][C:16]=3[CH:17]=2)=[O:30])=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 12734DiisopropylcarbodiimideHCID 56840192N-[(2,4-dichloro-3-isothiocyanatophenyl)methyl]-2,2-dimethylpropanamideHCID 86666472HCID 86666472, compound

Product 1

HCID 88531913HCID 88531913, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound is prepared in analogy to 6c from (R)—N-(4-trifluoromethoxyphenyl)-2-[3-fluoro-pyrrolidinyl]-4-(2,2-difluoro-ethylamino)-5-amino-benzoic acid amide (94 mg, 0.20 mmol), and N-(2,4-dichloro-3-isothiocyanato-benzyl)-2,2-dimethyl-propionamide (64 mg, 0.20 mmol), DIC (62 μL, 0.40 mmol) and THF (10 mL).

Sources & evidence

ORD record
ord-52564f561d654ea2b3f946a72c49b406
Source dataset
uspto-grants-2014_03
Patent number
US08674113B2

Reaction notes

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