HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → N-(3,3,3-trifluoro-propyl)-2-[3-trifluoromethyl-piperidinyl]-4-methylamino-5-nitro-benzoic acid amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 3-(Trifluoromethyl)piperidine | HCID 2760776 | — |
| Reactant | N-(3,3,3-Trifluoro-propyl)-2-chloro-4-methylamino-5-nitro-benzoic acid amide | HCID 67957674 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | N-(3,3,3-trifluoro-propyl)-2-[3-trifluoromethyl-piperidinyl]-4-methylamino-5-nitro-benzoic acid amide | HCID 86666474 | — |
Reaction Steps
The sub-title compound is prepared in analogy to 6a from N-(3,3,3-trifluoro-propyl)-2-chloro-4-methylamino-5-nitro-benzoic acid amide (80 mg, 0.246 mmol), 3-trifluormethyl-piperidine (150 mg, 0.98 mmol), DIPEA (0.34 mL, 2.0 mmol) and dioxane (5 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08674113B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-7e84ab4abad045daa36b066e443a6d50 |
| Source note | uspto-grants-2014_03 |