Diisopropylethylamine → N-(3,3,3-trifluoro-propyl)-2-[3-trifluoromethyl-piperidinyl]-4-methylamino-5-nitro-benzoic acid amide

HRID 1189663Notes

Reaction equation

HRID 1189663 reaction equation
[F:1][C:2]([F:21])([F:20])[CH2:3][CH2:4][NH:5][C:6](=[O:19])[C:7]1[CH:12]=[C:11]([N+:13]([O-:15])=[O:14])[C:10]([NH:16][CH3:17])=[CH:9][C:8]=1Cl.[F:22][C:23]([F:31])([F:30])[CH:24]1[CH2:29][CH2:28][CH2:27][NH:26][CH2:25]1.CCN(C(C)C)C(C)C>O1CCOCC1>[F:1][C:2]([F:21])([F:20])[CH2:3][CH2:4][NH:5][C:6](=[O:19])[C:7]1[CH:12]=[C:11]([N+:13]([O-:15])=[O:14])[C:10]([NH:16][CH3:17])=[CH:9][C:8]=1[N:26]1[CH2:27][CH2:28][CH2:29][CH:24]([C:23]([F:31])([F:30])[F:22])[CH2:25]1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 27607763-(Trifluoromethyl)piperidineHCID 67957674N-(3,3,3-Trifluoro-propyl)-2-chloro-4-methylamino-5-nitro-benzoic acid amide

Product 1

HCID 86666474N-(3,3,3-trifluoro-propyl)-2-[3-trifluoromethyl-piperidinyl]-4-methylamino-5-nitro-benzoic acid amide

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The sub-title compound is prepared in analogy to 6a from N-(3,3,3-trifluoro-propyl)-2-chloro-4-methylamino-5-nitro-benzoic acid amide (80 mg, 0.246 mmol), 3-trifluormethyl-piperidine (150 mg, 0.98 mmol), DIPEA (0.34 mL, 2.0 mmol) and dioxane (5 mL).

Sources & evidence

ORD record
ord-7e84ab4abad045daa36b066e443a6d50
Source dataset
uspto-grants-2014_03
Patent number
US08674113B2

Reaction notes

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