反应详情

A mixture of N-(trans-4-trifluoromethyl-cyclohexyl)-2-[N-methyl-N-(4-fluorobenzyl)amino]-4-methylamino-5-nitro-benzoic acid amide (80 mg, 0.166 mmol), SnCl2 (183 mg 0.81 mmol) and 5 mL EtOAc is stirred at reflux for 1 h. The mixture is filtered through a pad of celite and the celite pad is washed with EtOAc. The combined organic phases are dried with Na2SO4, filtered and concentrated. Yield: 68 mg. HPLC Rt=1.35 min (method A). MS m/z: 453 [M+H]+.

1. temperatureat reflux for 1 h
2. filtrationThe mixture is filtered through a pad of celite
3. washthe celite pad is washed with EtOAc
4. dry with materialThe combined organic phases are dried with Na2SO4
5. filtrationfiltered
6. concentrationconcentrated