Nitric Acid → 2-Chloro-4-fluoro-3-methyl-5-nitrobenzoic acid

HRID 1189676Notes

Reaction equation

HRID 1189676 reaction equation
[N+:1]([O-:4])(O)=[O:2].[Cl:5][C:6]1[C:14]([CH3:15])=[C:13]([F:16])[CH:12]=[CH:11][C:7]=1[C:8]([OH:10])=[O:9].OS(O)(=O)=O>>[Cl:5][C:6]1[C:14]([CH3:15])=[C:13]([F:16])[C:12]([N+:1]([O-:4])=[O:2])=[CH:11][C:7]=1[C:8]([OH:10])=[O:9]

Participants

4

Reactant 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 108453152-Chloro-4-fluoro-3-methylbenzoic acid

Product 1

HCID 105138312-Chloro-4-fluoro-3-methyl-5-nitrobenzoic acid

Procedure

Aq HNO3 (65%, 0.39 mL) is added at 0° C. to a mixture of 2-chloro-3-methyl-4-fluoro-benzoic acid (880 mg, 4.7 mmol) and 8 mL conc H2SO4 and it is stirred for 2 h without further cooling. The mixture is poured into ice water and the precipitate is collected by filtration and dried.

Workup

  1. filtrationthe precipitate is collected by filtration
  2. customdried

Sources & evidence

ORD record
ord-da14ae3dc166415aa27d3a794a378cf8
Source dataset
uspto-grants-2014_03
Patent number
US08674113B2

Reaction notes

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