HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitric Acid → 2-Chloro-4-fluoro-3-methyl-5-nitrobenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 2-Chloro-4-fluoro-3-methylbenzoic acid | HCID 10845315 | — |
| Product | 2-Chloro-4-fluoro-3-methyl-5-nitrobenzoic acid | HCID 10513831 | — |
Reaction Steps
Aq HNO3 (65%, 0.39 mL) is added at 0° C. to a mixture of 2-chloro-3-methyl-4-fluoro-benzoic acid (880 mg, 4.7 mmol) and 8 mL conc H2SO4 and it is stirred for 2 h without further cooling. The mixture is poured into ice water and the precipitate is collected by filtration and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08674113B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-da14ae3dc166415aa27d3a794a378cf8 |
| Source note | uspto-grants-2014_03 |