HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 178482285, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 3-Azabicyclo(3.1.0)hexane | HCID 13150523 | — |
| Reactant | HCID 178482283 | HCID 178482283 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 178482285 | HCID 178482285 | — |
Reaction Steps
The sub-title compound is prepared in analogy to 6a from N-(trans-4-trifluoromethyl-cyclohexyl)-2-chloro-3-methyl-4-methylamino-5-nitro-benzoic acid amide (250 mg, 0.64 mmol), 3-aza-bicyclo[3.1.0]hexane (151 mg, 1.27 mmol), DIPEA (0.44 mL, 2.5 mmol) and dioxane (8 mL). Yield: 130 mg. HPLC Rt=1.62 min (method H). MS m/z: 441 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08674113B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-c22ac89f41114d43bc8c69fdd6dbd618 |
| Source note | uspto-grants-2014_03 |