Diisopropylethylamine → HCID 178482285, compound

HRID 1189678Notes

Reaction equation

HRID 1189678 reaction equation
[F:1][C:2]([F:26])([F:25])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10](=[O:24])[C:11]2[CH:16]=[C:15]([N+:17]([O-:19])=[O:18])[C:14]([NH:20][CH3:21])=[C:13]([CH3:22])[C:12]=2Cl)[CH2:5][CH2:4]1.[CH:27]12[CH2:32][CH:31]1[CH2:30][NH:29][CH2:28]2.CCN(C(C)C)C(C)C>O1CCOCC1>[F:1][C:2]([F:26])([F:25])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10](=[O:24])[C:11]2[CH:16]=[C:15]([N+:17]([O-:19])=[O:18])[C:14]([NH:20][CH3:21])=[C:13]([CH3:22])[C:12]=2[N:29]2[CH2:30][CH:31]3[CH:27]([CH2:32]3)[CH2:28]2)[CH2:5][CH2:4]1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 131505233-Azabicyclo(3.1.0)hexaneHCID 178482283HCID 178482283, compound

Product 1

HCID 178482285HCID 178482285, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The sub-title compound is prepared in analogy to 6a from N-(trans-4-trifluoromethyl-cyclohexyl)-2-chloro-3-methyl-4-methylamino-5-nitro-benzoic acid amide (250 mg, 0.64 mmol), 3-aza-bicyclo[3.1.0]hexane (151 mg, 1.27 mmol), DIPEA (0.44 mL, 2.5 mmol) and dioxane (8 mL). Yield: 130 mg. HPLC Rt=1.62 min (method H). MS m/z: 441 [M+H]+.

Sources & evidence

ORD record
ord-c22ac89f41114d43bc8c69fdd6dbd618
Source dataset
uspto-grants-2014_03
Patent number
US08674113B2

Reaction notes

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