HCID 178482285, compound → HCID 178482278, compound

HRID 1189679Notes

Reaction equation

HRID 1189679 reaction equation
[F:1][C:2]([F:31])([F:30])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10](=[O:29])[C:11]2[CH:16]=[C:15]([N+:17]([O-])=O)[C:14]([NH:20][CH3:21])=[C:13]([CH3:22])[C:12]=2[N:23]2[CH2:28][CH:27]3[CH:25]([CH2:26]3)[CH2:24]2)[CH2:5][CH2:4]1>[Pd].CO>[F:30][C:2]([F:1])([F:31])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10](=[O:29])[C:11]2[CH:16]=[C:15]([NH2:17])[C:14]([NH:20][CH3:21])=[C:13]([CH3:22])[C:12]=2[N:23]2[CH2:24][CH:25]3[CH:27]([CH2:26]3)[CH2:28]2)[CH2:5][CH2:4]1

Participants

4

Reactant 1

HCID 178482285HCID 178482285, compound

Product 1

HCID 178482278HCID 178482278, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The sub-title compound is prepared in analogy to 6b from N-(trans-4-trifluoromethyl-cyclohexyl)-2-[3-aza-bicyclo[3.1.0]hex-3-yl]-3-methyl-4-methylamino-5-nitro-benzoic acid amide (130 mg, 0.295 mmol), Pd/C (50 mg), MeOH (40 mL) and 3 bar H2-atmosphere. Yield: 85 mg. HPLC Rt=1.31 min (method A). MS m/z: 411 [M+H]+.

Sources & evidence

ORD record
ord-ee7673fc989a4c3eabf4328804495e2a
Source dataset
uspto-grants-2014_03
Patent number
US08674113B2

Reaction notes

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