HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 178482279, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | HCID 178482286 | HCID 178482286 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178482279 | HCID 178482279 | — |
Reaction Steps
The sub-title compound is prepared in analogy to procedure 6b from (R)—N-(trans-4-trifluoromethyl-cyclohexyl)-2-[3-fluoro-pyrrolidinyl]-3-fluoro-4-methylamino-5-nitro-benzoic acid amide (230 mg, 0.51 mmol), Pd/C (20 mg), MeOH (15 mL), THF (5 mL) and 3 bar H2-atmosphere. Yield: 215 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08674113B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-c4cf2b3bbdd24c9db8e9bada7a6f2c4d |
| Source note | uspto-grants-2014_03 |