Methanol → HCID 178482279, compound

HRID 1189683Notes

Reaction equation

HRID 1189683 reaction equation
[F:1][C:2]([F:31])([F:30])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10](=[O:29])[C:11]2[CH:16]=[C:15]([N+:17]([O-])=O)[C:14]([NH:20][CH3:21])=[C:13]([F:22])[C:12]=2[N:23]2[CH2:27][CH2:26][C@@H:25]([F:28])[CH2:24]2)[CH2:5][CH2:4]1.CO>[Pd].C1COCC1>[F:31][C:2]([F:1])([F:30])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10](=[O:29])[C:11]2[CH:16]=[C:15]([NH2:17])[C:14]([NH:20][CH3:21])=[C:13]([F:22])[C:12]=2[N:23]2[CH2:27][CH2:26][C@@H:25]([F:28])[CH2:24]2)[CH2:5][CH2:4]1

Participants

5

Reactant 2

HCID 887MethanolHCID 178482286HCID 178482286, compound

Product 1

HCID 178482279HCID 178482279, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

The sub-title compound is prepared in analogy to procedure 6b from (R)—N-(trans-4-trifluoromethyl-cyclohexyl)-2-[3-fluoro-pyrrolidinyl]-3-fluoro-4-methylamino-5-nitro-benzoic acid amide (230 mg, 0.51 mmol), Pd/C (20 mg), MeOH (15 mL), THF (5 mL) and 3 bar H2-atmosphere. Yield: 215 mg.

Sources & evidence

ORD record
ord-c4cf2b3bbdd24c9db8e9bada7a6f2c4d
Source dataset
uspto-grants-2014_03
Patent number
US08674113B2

Reaction notes

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