Cesium carbonate → HCID 67956988, compound

HRID 1189692Notes

Reaction equation

HRID 1189692 reaction equation
[NH2:1][CH2:2][C:3]([CH3:6])([OH:5])[CH3:4].[F:7][C:8]([F:31])([F:30])[O:9][C:10]1[CH:15]=[CH:14][C:13]([NH:16][C:17](=[O:29])[C:18]2[CH:23]=[C:22]([N+:24]([O-:26])=[O:25])[C:21](F)=[CH:20][C:19]=2[Cl:28])=[CH:12][CH:11]=1.C([O-])([O-])=O.[Cs+].[Cs+]>CN(C=O)C>[F:30][C:8]([F:7])([F:31])[O:9][C:10]1[CH:15]=[CH:14][C:13]([NH:16][C:17](=[O:29])[C:18]2[CH:23]=[C:22]([N+:24]([O-:26])=[O:25])[C:21]([NH:1][CH2:2][C:3]([OH:5])([CH3:6])[CH3:4])=[CH:20][C:19]=2[Cl:28])=[CH:12][CH:11]=1

Participants

5

Reactant 3

HCID 10796Cesium carbonateHCID 951022-Propanol, 1-amino-2-methyl-HCID 67957548HCID 67957548, compound

Product 1

HCID 67956988HCID 67956988, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
50 °C

Procedure

A mixture of 1-amino-2-methyl-propan-2-ol (184 mg, 2.06 mmol), N-(4-trifluoromethoxy-phenyl)-2-chloro-4-fluoro-5-nitro-benzoic acid amide (650 mg, 1.7 mmol), Cs2CO3 (839 mg, 2.6 mmol) and 10 mL DMF is stirred for 1 h at 50° C., poured into ice water, concentrated and the resulting precipitate is collected by filtration, washed with water and dried.

Workup

  1. concentrationconcentrated
  2. filtrationthe resulting precipitate is collected by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-cd802f9db24344fd8f67a91db4570cb5
Source dataset
uspto-grants-2014_03
Patent number
US08674113B2

Reaction notes

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