Morpholine → HCID 67957327, compound

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Reaction Steps

The sub-title compound is prepared in analogy to 103a from N-(4-trifluoromethoxy-phenyl)-2-chloro-4-(2-hydroxy-2-methyl-propylamino)-5-nitro-benzoic acid amide (300 mg, 0.67 mmol), morpholine (233 μL, 2.7 mmol), DIPEA (1.1 mL, 6.7 mmol) and MeCN (3 mL) in a microwave oven at 150° C. (45 min). Yield: 324 mg. HPLC Rt=1.58 min (method H). MS m/z: 499 [M+H]+.

Provenance & Evidence