Morpholine → HCID 67957327, compound

HRID 1189693Notes

Reaction equation

HRID 1189693 reaction equation
[F:1][C:2]([F:30])([F:29])[O:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:28])[C:12]2[CH:17]=[C:16]([N+:18]([O-:20])=[O:19])[C:15]([NH:21][CH2:22][C:23]([OH:26])([CH3:25])[CH3:24])=[CH:14][C:13]=2Cl)=[CH:6][CH:5]=1.[NH:31]1[CH2:36][CH2:35][O:34][CH2:33][CH2:32]1.CCN(C(C)C)C(C)C>CC#N>[F:1][C:2]([F:30])([F:29])[O:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:28])[C:12]2[CH:17]=[C:16]([N+:18]([O-:20])=[O:19])[C:15]([NH:21][CH2:22][C:23]([OH:26])([CH3:25])[CH3:24])=[CH:14][C:13]=2[N:31]2[CH2:36][CH2:35][O:34][CH2:33][CH2:32]2)=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 8083MorpholineHCID 81531DiisopropylethylamineHCID 67956988HCID 67956988, compound

Product 1

HCID 67957327HCID 67957327, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The sub-title compound is prepared in analogy to 103a from N-(4-trifluoromethoxy-phenyl)-2-chloro-4-(2-hydroxy-2-methyl-propylamino)-5-nitro-benzoic acid amide (300 mg, 0.67 mmol), morpholine (233 μL, 2.7 mmol), DIPEA (1.1 mL, 6.7 mmol) and MeCN (3 mL) in a microwave oven at 150° C. (45 min). Yield: 324 mg. HPLC Rt=1.58 min (method H). MS m/z: 499 [M+H]+.

Sources & evidence

ORD record
ord-b3ebe248a732467886b184e3d2659f23
Source dataset
uspto-grants-2014_03
Patent number
US08674113B2

Reaction notes

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