Diisopropylcarbodiimide → HCID 67957647, compound

HRID 1189695Notes

Reaction equation

HRID 1189695 reaction equation
[F:1][C:2]([F:33])([F:32])[O:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:31])[C:12]2[CH:17]=[C:16]([NH2:18])[C:15]([NH:19][CH2:20][C:21]([OH:24])([CH3:23])[CH3:22])=[CH:14][C:13]=2[N:25]2[CH2:30][CH2:29][O:28][CH2:27][CH2:26]2)=[CH:6][CH:5]=1.[Cl:34][C:35]1[C:48]([N:49]=[C:50]=S)=[C:47]([Cl:52])[CH:46]=[CH:45][C:36]=1[CH2:37][NH:38][C:39](=[O:44])[C:40]([CH3:43])([CH3:42])[CH3:41].CC(C)N=C=NC(C)C>CC#N>[F:33][C:2]([F:1])([F:32])[O:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([C:12]2[C:13]([N:25]3[CH2:30][CH2:29][O:28][CH2:27][CH2:26]3)=[CH:14][C:15]3[N:19]([CH2:20][C:21]([OH:24])([CH3:23])[CH3:22])[C:50]([NH:49][C:48]4[C:47]([Cl:52])=[CH:46][CH:45]=[C:36]([CH2:37][NH:38][C:39](=[O:44])[C:40]([CH3:41])([CH3:42])[CH3:43])[C:35]=4[Cl:34])=[N:18][C:16]=3[CH:17]=2)=[O:31])=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 12734DiisopropylcarbodiimideHCID 56840192N-[(2,4-dichloro-3-isothiocyanatophenyl)methyl]-2,2-dimethylpropanamideHCID 67957429HCID 67957429, compound

Product 1

HCID 67957647HCID 67957647, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The title compound is prepared in analogy to 6c from N-(4-trifluoromethoxyphenyl)-2-(morpholinyl)-4-(2-hydroxy-2-methyl-propylamino)-5-amino-benzoic acid amide (94 mg, 0.20 mmol), and N-(2,4-dichloro-3-isothiocyanato-benzyl)-2,2-dimethyl-propionamide (64 mg, 0.20 mmol), DIC (31 μL, 0.20 mmol) and MeCN (5 mL).

Sources & evidence

ORD record
ord-fd569d0cf77840a8a6e562e5774a11dd
Source dataset
uspto-grants-2014_03
Patent number
US08674113B2

Reaction notes

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