HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 86666489, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-(Trifluoromethyl)piperidine | HCID 136469 | — |
| Reactant | N-(3,3,3-Trifluoro-propyl)-2-chloro-4-methylamino-5-nitro-benzoic acid amide | HCID 67957674 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 86666489 | HCID 86666489 | — |
Reaction Steps
The sub-title compound is prepared in analogy to 6a from N-(3,3,3-trifluoro-propyl)-2-chloro-4-methylamino-5-nitro-benzoic acid amide (compound 81a; 2.0 g, 6.5 mmol), 4-trifluormethyl-piperidine×HCl (2.45 g, 13 mmol), DIPEA (4.9 mL, 29 mmol) and MeCN (25 mL) in a pressure flask at 80° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08674113B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-14e015d1f8564c8fbfd2647c65810aac |
| Source note | uspto-grants-2014_03 |