Hydrochloric Acid → HCID 86666489, compound

HRID 1189696Notes

Reaction equation

HRID 1189696 reaction equation
[F:1][C:2]([F:21])([F:20])[CH2:3][CH2:4][NH:5][C:6](=[O:19])[C:7]1[CH:12]=[C:11]([N+:13]([O-:15])=[O:14])[C:10]([NH:16][CH3:17])=[CH:9][C:8]=1Cl.[F:22][C:23]([F:31])([F:30])[CH:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1.Cl.CCN(C(C)C)C(C)C>CC#N>[F:1][C:2]([F:21])([F:20])[CH2:3][CH2:4][NH:5][C:6](=[O:19])[C:7]1[CH:12]=[C:11]([N+:13]([O-:15])=[O:14])[C:10]([NH:16][CH3:17])=[CH:9][C:8]=1[N:27]1[CH2:28][CH2:29][CH:24]([C:23]([F:31])([F:30])[F:22])[CH2:25][CH2:26]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 81531DiisopropylethylamineHCID 1364694-(Trifluoromethyl)piperidineHCID 67957674N-(3,3,3-Trifluoro-propyl)-2-chloro-4-methylamino-5-nitro-benzoic acid amide2×

Product 1

HCID 86666489HCID 86666489, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The sub-title compound is prepared in analogy to 6a from N-(3,3,3-trifluoro-propyl)-2-chloro-4-methylamino-5-nitro-benzoic acid amide (compound 81a; 2.0 g, 6.5 mmol), 4-trifluormethyl-piperidine×HCl (2.45 g, 13 mmol), DIPEA (4.9 mL, 29 mmol) and MeCN (25 mL) in a pressure flask at 80° C.

Sources & evidence

ORD record
ord-14e015d1f8564c8fbfd2647c65810aac
Source dataset
uspto-grants-2014_03
Patent number
US08674113B2

Reaction notes

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