反应详情

A mixture of N-(3,3,3-trifluoro-propyl)-2-[4-trifluoromethyl-piperidinyl]-4-methylamino-5-nitro-benzoic acid amide (2.5 g, 5.7 mmol), Pd/C (200 mg), THF (10 mL) and MeOH (100 mL) is stirred for 2 h under 3 bar H2-atmosphere. The mixture is filtered, and the filtrate is concentrated. Yield: 2.3 g. HPLC Rt=1.25 min (method A). MS m/z: 413 [M+H]+.

1. filtrationThe mixture is filtered
2. concentrationthe filtrate is concentrated