Hydrochloric Acid → HCID 86666492, compound

Participants

Reaction Steps

A mixture of N-(3,3,3-trifluoropropyl)-2-{2,6-dichloro-3-[(tert.-butoxycarbonylamino)-methyl]-phenylamino}-6-[4-trifluoromethyl-piperidinyl]-1-methyl-1H-benzimidazole-5-carboxylic acid amide (2.73 g, 3.8 mmol), 15 mL 6M aq HCl and 15 mL THF is stirred for 2 h, concentrated and the sub title compound is purified by chromatography (silica gel, DCM→DCM/10% EtOH+few drops of NH4OH). Yield: 2.3 g. Rf=0.27 (DCM/EtOH/NH4OH 90:10:1). MS m/z: 712 [M+H]+.

Provenance & Evidence