Diisopropylethylamine → HCID 178482175, compound

HRID 1189700Notes

Reaction equation

HRID 1189700 reaction equation
[F:1][C:2]([F:25])([F:24])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10](=[O:23])[C:11]2[CH:16]=[C:15]([N+:17]([O-:19])=[O:18])[C:14]([NH:20][CH3:21])=[CH:13][C:12]=2Cl)[CH2:5][CH2:4]1.[CH:26]12[CH2:31][CH:30]1[CH2:29][NH:28][CH2:27]2.CCN(C(C)C)C(C)C>O1CCOCC1>[F:1][C:2]([F:25])([F:24])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10](=[O:23])[C:11]2[C:16]([C:26]34[CH2:31][CH:30]3[CH2:29][NH:28][CH2:27]4)=[C:15]([N+:17]([O-:19])=[O:18])[C:14]([NH:20][CH3:21])=[CH:13][CH:12]=2)[CH2:5][CH2:4]1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 131505233-Azabicyclo(3.1.0)hexaneHCID 178482185HCID 178482185, compound2×

Product 1

HCID 178482175HCID 178482175, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The sub-title compound is prepared in analogy to procedure 6a from N-(trans-4-trifluoromethyl-cyclohexyl)-2-chloro-4-methylamino-5-nitro-benzoic acid amide (compound 20b; 1.6 g, 4.2 mmol), 3-aza-bicyclo[3.1.0]hexane (1.00 g, 5.3 mmol), DIPEA (3.0 mL, 17 mmol) and dioxane (40 mL) at reflux (overnight).

Workup

  1. temperatureat reflux (overnight)

Sources & evidence

ORD record
ord-198c7afec57249038ace82c040b518a2
Source dataset
uspto-grants-2014_03
Patent number
US08674113B2

Reaction notes

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