Hydrochloric Acid → 2-{2,6-Dichloro-3-[aminomethyl]-phenylamino}-6-[4-trifluoromethyl-piperidinyl]-1-methyl-1H-benzimidazole-5-carboxylic acid ethyl ester

Participants

Role	Name	HCID	Charge
Reactant	Hydrochloric Acid	HCID 313	—
Reactant	HCID 67957208	HCID 67957208	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	2-{2,6-Dichloro-3-[aminomethyl]-phenylamino}-6-[4-trifluoromethyl-piperidinyl]-1-methyl-1H-benzimidazole-5-carboxylic acid ethyl ester	HCID 67957511	—

Reaction Steps

A mixture of 2-{2,6-dichloro-3-[(tert.-butoxycarbonylamino)-methyl]-phenylamino}-6-[4-trifluoromethyl-piperidinyl]-1-methyl-1H-benzimidazole-5-carboxylic acid ethyl ester (6.95 g, 11 mmol) and 26 mL 4M HCl in dioxane is stirred overnight. Then the organic phase is concentrated and the crude sub-title compound is directly used in the next step.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08674113B2
Source dataset	uspto-grants-2014_03
ORD ID	ord-5894287587a54e2aae7b9a89eb8f5b71
Source note	uspto-grants-2014_03