HRID1189704

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：CCOC(=O)c1cc2nc(Nc3c(Cl)ccc(CNC(=O)OC(C)(C)C)c3Cl)n(C)c2cc1N1CCC(C(F)(F)F)CC1

HCID67957208

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)c1cc2nc(Nc3c(Cl)ccc(CN)c3Cl)n(C)c2cc1N1CCC(C(F)(F)F)CC1

HCID67957511

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

A mixture of 2-{2,6-dichloro-3-[(tert.-butoxycarbonylamino)-methyl]-phenylamino}-6-[4-trifluoromethyl-piperidinyl]-1-methyl-1H-benzimidazole-5-carboxylic acid ethyl ester (6.95 g, 11 mmol) and 26 mL 4M HCl in dioxane is stirred overnight. Then the organic phase is concentrated and the crude sub-title compound is directly used in the next step.

WORKUP

后处理

concentrationThen the organic phase is concentrated