HRID1189763

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID254532

Naphthalen-1-ylboronic acid

C10H9BO2

HCID737253

4-(4-Methylpiperazino)aniline

C11H17N3

结构：O=C(O)c1ccc(-c2cccc3ccccc23)c2nccnc12

HCID66914606

未命名化合物

PRODUCTS

生成物

结构：CN1CCN(c2ccc(NC(=O)c3ccc(-c4cccc5ccccc45)c4nccnc34)cc2)CC1

HCID44515355

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21226129

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in analogy to the procedure described in in Step 14.1 but stirring the reaction mixture overnight and using 4-(4-methylpiperazin-1-yl)-aniline (WO2006000420) and 8-naphthalen-1-yl-quinoxaline-5-carboxylic acid. The latter compound was synthesized as described in Steps 1.2-1.7 but using 1-naphtylboronic acid in Step 1.4. Title compound: ESI-MS: 474.0 [M+H]+; tR=4.34 min (System 1); TLC: Rf=0.45 (DCM/MeOH/NH3aq, 94:5:1).

WORKUP

后处理

customThe title compound was prepared in analogy to the procedure
customThe latter compound was synthesized

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f2b1c44a4087448889791a35ef2c5df8
来源数据集: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08674099B2
来源说明: uspto-grants-2014_03

反应 SMILES

[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:14]=[CH:13][C:11]([NH2:12])=[CH:10][CH:9]=2)[CH2:4][CH2:3]1.[C:15]1([C:25]2[C:34]3[N:33]=[CH:32][CH:31]=[N:30][C:29]=3[C:28]([C:35](O)=[O:36])=[CH:27][CH:26]=2)[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:18]=[CH:17][CH:16]=1.C1(B(O)O)C2C(=CC=CC=2)C=CC=1>C(Cl)Cl.CO>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([C:8]2[CH:14]=[CH:13][C:11]([NH:12][C:35]([C:28]3[C:29]4[N:30]=[CH:31][CH:32]=[N:33][C:34]=4[C:25]([C:15]4[C:24]5[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=5)[CH:18]=[CH:17][CH:16]=4)=[CH:26][CH:27]=3)=[O:36])=[CH:10][CH:9]=2)[CH2:6][CH2:7]1