化工社化工社 化学情報印刷レポート · 研究参考用
1-Naphthaleneboronic acid → 8-Naphthalen-1-yl-quinoxaline-5-carboxylic acid [4-(4-methyl-piperazin-1-yl)phenyl]-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Naphthaleneboronic acid | HCID 254532 | — |
| 反応物 | 4-(4-Methylpiperazin-1-yl)aniline | HCID 737253 | — |
| 反応物 | 8-Naphthalen-1-yl-quinoxaline-5-carboxylic acid | HCID 66914606 | — |
| 溶媒 | Dichloromethane methanol | HCID 21226129 | — |
| 生成物 | 8-Naphthalen-1-yl-quinoxaline-5-carboxylic acid [4-(4-methyl-piperazin-1-yl)phenyl]-amide | HCID 44515355 | — |
反応手順
The title compound was prepared in analogy to the procedure described in in Step 14.1 but stirring the reaction mixture overnight and using 4-(4-methylpiperazin-1-yl)-aniline (WO2006000420) and 8-naphthalen-1-yl-quinoxaline-5-carboxylic acid. The latter compound was synthesized as described in Steps 1.2-1.7 but using 1-naphtylboronic acid in Step 1.4. Title compound: ESI-MS: 474.0 [M+H]+; tR=4.34 min (System 1); TLC: Rf=0.45 (DCM/MeOH/NH3aq, 94:5:1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08674099B2 |
| 出典データセット | uspto-grants-2014_03 |
| ORD ID | ord-f2b1c44a4087448889791a35ef2c5df8 |
| 出典メモ | uspto-grants-2014_03 |