HRID1190024

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3939

Lithium hydroxide anhydrous

HLiO

结构：COC(=O)c1sccc1N(C(=O)[C@H]1CC[C@H](C)CC1)[C@H]1CC[C@H](O)CC1

HCID178499317

未命名化合物

PRODUCTS

生成物

结构：C[C@H]1CC[C@H](C(=O)N(c2ccsc2C(=O)O)[C@H]2CC[C@H](O)CC2)CC1

HCID178461284

未命名化合物

PROCEDURE

实验过程

The product from step I (30 mg) was hydrolyzed with lithium hydroxide as described earlier (example 3, step VIII) to afford after column purification on silica gel (CH2Cl2-MeOH) 16 mg (57%) of 3-[(trans-4-hydroxy-cyclohexyl)-(trans-4-methyl-cyclohexanecarbonyl)-amino]-thiophene-2-carboxylic acid.

WORKUP

后处理

customto afford
customafter column purification on silica gel (CH2Cl2-MeOH) 16 mg (57%) of 3-[(trans-4-hydroxy-cyclohexyl)-(trans-4-methyl-cyclohexanecarbonyl)-amino]-thiophene-2-carboxylic acid