Lithium Hydroxide → HCID 178468174, compound

HRID 1190025Notes

Reaction equation

HRID 1190025 reaction equation
C([O:3][C:4]([C:6]1[S:7][C:8](Br)=[CH:9][C:10]=1[N:11]([C@H:21]1[CH2:26][CH2:25][C@H:24]([O:27][CH2:28][CH3:29])[CH2:23][CH2:22]1)[C:12]([C@H:14]1[CH2:19][CH2:18][C@H:17]([CH3:20])[CH2:16][CH2:15]1)=[O:13])=[O:5])C.[OH-].[Li+]>>[C:14]1([C:8]2[S:7][C:6]([C:4]([OH:3])=[O:5])=[C:10]([N:11]([C@H:21]3[CH2:22][CH2:23][C@H:24]([O:27][CH2:28][CH3:29])[CH2:25][CH2:26]3)[C:12]([C@H:14]3[CH2:15][CH2:16][C@H:17]([CH3:20])[CH2:18][CH2:19]3)=[O:13])[CH:9]=2)[CH2:19][CH2:18][CH2:17][CH2:16][CH:15]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 178470550HCID 178470550, compound

Product 1

HCID 178468174HCID 178468174, compoundYield 113%

Procedure

The ester from Step II (173 mg, 0.34 mmol) was hydrolysed by lithium hydroxide as previously described (example 3, step VIII) to give 91 mg of 5-cyclohex-1-enyl-3-[(trans-4-ethoxy-cyclohexyl)-(trans-4-methyl-cyclohexanecarbonyl)-amino]-thiophene-2-carboxylic acid.

Sources & evidence

ORD record
ord-71317965aa49473f9f8750c97035742c
Source dataset
uspto-grants-2014_03
Patent number
US08674118B2

Reaction notes

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