Lithium Hydroxide → HCID 178461271, compound

HRID 1190036Notes

Reaction equation

C[O:2][C:3]([C:5]1[S:6][C:7]([C:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH:29]=2)=[CH:8][C:9]=1[N:10]([CH:20]1[CH2:25][CH2:24][N:23]([CH:26]=[O:27])[CH2:22][CH2:21]1)[C:11]([C@H:13]1[CH2:18][CH2:17][C@H:16]([CH3:19])[CH2:15][CH2:14]1)=[O:12])=[O:4].[OH-].[Li+]>>[C:28]1([C:7]2[S:6][C:5]([C:3]([OH:4])=[O:2])=[C:9]([N:10]([CH:20]3[CH2:21][CH2:22][N:23]([CH:26]=[O:27])[CH2:24][CH2:25]3)[C:11]([C@H:13]3[CH2:18][CH2:17][C@H:16]([CH3:19])[CH2:15][CH2:14]3)=[O:12])[CH:8]=2)[CH2:33][CH2:32][CH2:31][CH2:30][CH:29]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 178499274HCID 178499274, compound

Product 1

HCID 178461271HCID 178461271, compound

Procedure

5-Cyclohex-1-enyl-3-[(1-formyl-piperidin-4-yl)-(trans-4-methyl-cyclohexane-carbonyl)-amino]-thiophene-2-carboxylic acid methyl ester was hydrolysed with lithium hydroxide according to previously described procedures (example 3, step VIII) to give the title compound.

Sources & evidence

ORD record: ord-4b823162bf3a44b982c47082fb7d076c
Source dataset: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08674118B2

Reaction notes

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