Thionyl Chloride → HCID 178462737, compound

HRID 1190193Notes

Reaction equation

HRID 1190193 reaction equation
[CH3:1][C:2]1([CH3:28])[CH2:7][CH2:6][C:5]([C:8]2[C:13]([NH:14][C:15]([C:17]3[NH:18][C:19]([C:22]#[N:23])=[CH:20][N:21]=3)=[O:16])=[CH:12][CH:11]=[C:10]([C:24](O)([CH3:26])[CH3:25])[N:9]=2)=[CH:4][CH2:3]1.[CH2:29]([N:31]1[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1)[CH3:30].S(Cl)(Cl)=O>C(Cl)Cl>[CH3:1][C:2]1([CH3:28])[CH2:7][CH2:6][C:5]([C:8]2[C:13]([NH:14][C:15]([C:17]3[NH:21][CH:20]=[C:19]([C:22]#[N:23])[N:18]=3)=[O:16])=[CH:12][CH:11]=[C:10]([C:24]([N:34]3[CH2:35][CH2:36][N:31]([CH2:29][CH3:30])[CH2:32][CH2:33]3)([CH3:26])[CH3:25])[N:9]=2)=[CH:4][CH2:3]1

Participants

5

Reactant 3

HCID 24386Thionyl ChlorideHCID 791961-EthylpiperazineHCID 59457539HCID 59457539, compound

Product 1

HCID 178462737HCID 178462737, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound is prepared from 5-cyano-1H-imidazole-2-carboxylic acid [2-(4,4-dimethyl-cyclohex-1-enyl)-6-(1-hydroxy-1-methyl-ethyl)-pyridin-3-yl]-amide (as prepared in the previous step), N-ethylpiperizine, and thionyl chloride in DCM solvent according to the procedure in Example 14, step (e).

Sources & evidence

ORD record
ord-3aa5da12e7cb4ae0baf3b85ef6cec0c2
Source dataset
uspto-grants-2014_03
Patent number
US08674100B2

Reaction notes

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