HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Azidotetrafluorobenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 4-azido-2,3,5,6-tetrafluorobenzoate | HCID 129750 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Azidotetrafluorobenzoic acid | HCID 2762578 | 85.7% |
Reaction Steps
A solution of 2 (1.67 g, 6.7 mmol) with 10% (w/v) NaOH (4 mL) in MeOH (20 mL) was stirred overnight at room temperature. The solution was acidified by 2 M HCl in an ice bath to pH<1 and extracted with CHCl3 (3×10 mL). The extracts were dried with Na2SO4, and the mixture was filtered. Solvent was evaporated to give 3 as a white solid (1.35 g, yield=85%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08679859B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-b4af7821f2a24bf68c29b29db80785c9 |
| Source note | uspto-grants-2014_03 |