HCID 69292925, compound → HCID 69292992, compound

HRID 1190795Notes

Reaction equation

HRID 1190795 reaction equation
[ClH:1].[C:2]([NH:6][C:7](=[O:23])[C:8]1[CH:13]=[CH:12][C:11]([C:14]2[C:15]3[N:16]([CH:20]=[N:21][CH:22]=3)[CH2:17][CH2:18][CH:19]=2)=[CH:10][CH:9]=1)([CH3:5])([CH3:4])[CH3:3]>C(O)C.[Pd]>[ClH:1].[C:2]([NH:6][C:7](=[O:23])[C:8]1[CH:9]=[CH:10][C:11]([CH:14]2[CH2:19][CH2:18][CH2:17][N:16]3[CH:20]=[N:21][CH:22]=[C:15]23)=[CH:12][CH:13]=1)([CH3:5])([CH3:3])[CH3:4]

Participants

4

Reactant 1

HCID 69292925HCID 69292925, compound

Product 1

HCID 69292992HCID 69292992, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 1.79 mmol of N-tert-Butyl-4-(5,6-dihydro-imidazo[1,5-a]pyridin-8-yl)-benzamide hydrochloride in 8 ml of ethanol is mixed with 270 mg of 10% Pd/C, and the reaction mixture is then hydrogenated at 20-25° C. under atmospheric pressure for 8 hours. The reaction mixture is clarified by filtration and the filtrate is evaporated. The crude title compound is obtained as a brown solid. Rf=0.35 (toluene:methanol=85:15), Rt=5.54.

Workup

  1. filtrationThe reaction mixture is clarified by filtration
  2. customthe filtrate is evaporated

Sources & evidence

ORD record
ord-1097982215aa44be98f75db8f62cc954
Source dataset
uspto-grants-2014_03
Patent number
US08680079B2

Reaction notes

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