Hydrochloric Acid → HCID 69483002, compound

Participants

Reaction Steps

5 ml of conc. HCl are added dropwise to a solution of 0.31 g of 8-[2-(1,1-dimethoxyethyl)thiazol-5-yl]-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-8-ol and 20 ml of 1:1 acetone/water at room temperature, and the mixture is stirred for 2 hours. The reaction mixture is evaporated—the residue is mixed with saturated aqueous sodium carbonate solution and extracted with ethyl acetate (3×). The combined organic phases are dried with sodium sulphate and evaporated. The title compound is identified from the residue by flash chromatography (SiO2 60F) on the basis of the Rf.

Provenance & Evidence