Trifluoroacetic acid → HCID 70975533, compound

HRID 1190804Notes

Reaction equation

HRID 1190804 reaction equation
[C:1]([C:3]1[CH:30]=[CH:29][C:6]([CH2:7][N:8]2[C:16]3[C:11](=[N:12][CH:13]=[CH:14][C:15]=3[N:17]3[CH2:22][CH2:21][CH2:20][C@@H:19]([NH:23]C(=O)O)[CH2:18]3)N(C)[C:9]2=[O:28])=[CH:5][CH:4]=1)#[N:2].[F:31][C:32]([F:37])([F:36])[C:33]([OH:35])=[O:34]>>[F:31][C:32]([F:37])([F:36])[C:33]([OH:35])=[O:34].[NH2:23][CH:19]1[CH2:20][CH2:21][CH2:22][N:17]([C:15]2[CH:14]=[CH:13][N:12]=[C:11]3[C@@H:32]([CH3:33])[C:9](=[O:28])[N:8]([CH2:7][C:6]4[CH:29]=[CH:30][C:3]([C:1]#[N:2])=[CH:4][CH:5]=4)[C:16]=23)[CH2:18]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86673550HCID 86673550, compound

Product 1

HCID 70975533HCID 70975533, compoundYield 99%

Procedure

The operation referred to the step (6) described in Example 1. 348 mg (R)-1-[1-(4-cyanobenzyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl]piperidin-3-yl carbamic acid ter.-butyl ester (0.75 mmol) and 2.0 mL trifluoroacetic acid were charged to afford 270 mg titled product with a yield of 99%.

Sources & evidence

ORD record
ord-4bcebed90d6a405f99c3c82c28b8a45b
Source dataset
uspto-grants-2014_03
Patent number
US08680089B2

Reaction notes

Loading…