Trifluoroacetic acid → HCID 70975502, compound

HRID 1190806Notes

Reaction equation

HRID 1190806 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([CH:28]=[CH:29][CH:30]=1)[CH2:6][N:7]1[C:15]2[C:10](=[N:11][CH:12]=[CH:13][C:14]=2[N:16]2[CH2:21][CH2:20][CH2:19][C@@H:18]([NH:22]C(=O)O)[CH2:17]2)N(C)[C:8]1=[O:27])#[N:2].[F:31][C:32]([F:37])([F:36])[C:33]([OH:35])=[O:34]>>[F:31][C:32]([F:37])([F:36])[C:33]([OH:35])=[O:34].[NH2:22][CH:18]1[CH2:19][CH2:20][CH2:21][N:16]([C:14]2[CH:13]=[CH:12][N:11]=[C:10]3[C@@H:32]([CH3:33])[C:8](=[O:27])[N:7]([CH2:6][C:5]4[CH:4]=[C:3]([CH:30]=[CH:29][CH:28]=4)[C:1]#[N:2])[C:15]=23)[CH2:17]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86673551HCID 86673551, compound

Product 1

HCID 70975502HCID 70975502, compoundYield 50%

Procedure

The operation referred to the step (6) described in Example 1. 290 mg (R)-1-[1-(3-cyanobenzyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl]piperidin-3-yl carbamic acid ter.-butyl ester (0.63 mmol) and 1.0 mL trifluoroacetic acid were charged to afford 150 mg titled product with a yield of 50%.

Sources & evidence

ORD record
ord-dc927f264f9c46fa8f97d29065427794
Source dataset
uspto-grants-2014_03
Patent number
US08680089B2

Reaction notes

Loading…