tert-Butyl piperazine-1-carboxylate → HCID 84103730, compound

HRID 1190815Notes

Reaction equation

HRID 1190815 reaction equation
[Cl:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[C:12]([O:16][C:17]([N:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1)=[O:18])([CH3:15])([CH3:14])[CH3:13]>>[C:12]([O:16][C:17]([N:19]1[CH2:24][CH2:23][N:22]([C:6]2[CH:5]=[CH:4][N:3]=[C:2]([Cl:1])[C:7]=2[N+:8]([O-:10])=[O:9])[CH2:21][CH2:20]1)=[O:18])([CH3:15])([CH3:13])[CH3:14]

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 105357732,4-Dichloro-3-nitropyridine

Product 1

HCID 84103730HCID 84103730, compoundYield 94.7%

Procedure

The specific operation referred to the step (1) described in Example 1 for details. 2,4-dichloro-3-nitropyridine (772 mg, 4.0 mmol), and piperazine-1-carboxylic acid tert-butyl ester (744 mg, 4.0 mmol) were charged to afford 1.299 g crude product with a yield of 94.7%, which was directly used in the subsequent reaction.

Sources & evidence

ORD record
ord-aae41e8f91074ffe92a54aab541b8c6d
Source dataset
uspto-grants-2014_03
Patent number
US08680089B2

Reaction notes

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