反应详情

HSB-9 and HSB-10: Sodium methoxide was added in one portion to a mixture of 2H-1,4-benzoxazin-3(4H)-one (10 mmol) and 4-dimethylamino benzaldehyde (16 mmol) in dry DMF (10 ml). The reaction mixture was refluxed overnight, then cooled to room temperature and poured into crushed ice and left overnight in the refrigerator. The precipitated solid was collected by filtration, washed with water and dried. The crude product was purified by recrystallisation from ethanol (30% yield) and DMF-ethanol (40% yield) respectively (40% yield).

1. temperatureThe reaction mixture was refluxed overnight
2. additionpoured
3. custominto crushed ice
4. filtrationThe precipitated solid was collected by filtration
5. washwashed with water
6. customdried