Trifluoroacetic acid → HCID 86707727, compound

Participants

Reaction Steps

To a solution of Compound 26c (100 mg, 0.32 mmol) in DCM (1 mL) was added TFA (1 mL) and the reaction mixture stirred for 1 h. The mixture was concentrated under reduced pressure, co-evaporated with toluene under reduced pressure, then dried under high vacuum to give Compound 26a (89 mg, 100% yield). LCMS=0.9 min using analytical method (B), 255.1 (M+H). 1H NMR (400 MHz, DMSO-d6) δ 12.50 (br. s., 1H), 8.45 (s, 1H), 4.37-4.00 (m, 2H), 2.88 (d, J=16.8 Hz, 1H), 2.60 (d, J=17.1 Hz, 1H), 1.31 (s, 3H).

Provenance & Evidence