17551-00-7 → HCID 86707738, compound

HRID 1190846Notes

Reaction equation

HRID 1190846 reaction equation
[F:1][C:2]1[C:7]2[N:8]=[C:9]([CH2:11][C:12]([NH:14][NH2:15])=[O:13])[S:10][C:6]=2[CH:5]=[C:4]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:3]=1.[S:22]([CH2:26][C:27](O)=O)(=[O:25])(=[O:24])[NH2:23]>>[F:1][C:2]1[C:7]2[N:8]=[C:9]([CH2:11][C:12]3[O:13][C:27]([CH2:26][S:22]([NH2:23])(=[O:25])=[O:24])=[N:15][N:14]=3)[S:10][C:6]=2[CH:5]=[C:4]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 1108396117551-00-7HCID 86707739HCID 86707739, compound

Product 1

HCID 86707738HCID 86707738, compound

Procedure

Compound 90e was prepared from Compound 90d and 2-sulfamoylacetic acid using the procedure given for Compound 1b. LCMS=1.78 min using analytical method (Q), 405.1 (M+H). 1H NMR (500 MHz, CD3OD) δ 8.07 (d, J=1.7 Hz, 1H), 7.74-7.67 (m, 2H), 7.56 (dd, J=12.0, 1.5 Hz, 1H), 7.52-7.43 (m, 2H), 7.43-7.36 (m, 1H), 4.94-4.88 (m, 2H), 4.78-4.74 (m, 2H).

Workup

  1. customLCMS=1.78 min

Sources & evidence

ORD record
ord-9fc591ef433c4d34a7021c9e45dc5f30
Source dataset
uspto-grants-2014_03
Patent number
US08680090B2

Reaction notes

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