HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,7-Dichloroquinoline → 3-Amino-5-[(7-chloroquinolin-4-yl)amino]benzonitrile hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,7-Dichloroquinoline | HCID 6866 | — |
| Reactant | 3,5-Diaminobenzonitrile | HCID 12897329 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-Amino-5-[(7-chloroquinolin-4-yl)amino]benzonitrile hydrochloride | HCID 67248348 | 74.3% |
Reaction Steps
3,5-Diaminobenzonitrile (500 mg, 3.76 mmol) and 4,7-dichloroquinoline (744 mg, 1 eq) were stirred at room temperature in 50 mL of ethanol for 18 h. The precipitate was removed by filtration to yield expected compound as a yellow powder (925 mg, 74% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08680095B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-e9d6932425db4a00a94ece4326dabe77 |
| Source note | uspto-grants-2014_03 |