HCID 28343695, compound → HCID 58495679, compound

HRID 1190947Notes

Reaction equation

HRID 1190947 reaction equation
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]2[CH2:6][CH2:7][N:8]([C:11](=[O:16])[C:12]([F:15])([F:14])[F:13])[CH2:9][CH2:10][C:4]=2[C:3]=1OS(C(F)(F)F)(=O)=O.[CH3:27][CH:28]([CH3:40])[CH2:29][C:30]([C:32]1[CH:39]=[CH:38][C:35]([CH2:36][NH2:37])=[CH:34][CH:33]=1)=[O:31]>>[Cl:1][C:2]1[CH:18]=[CH:17][C:5]2[CH2:6][CH2:7][N:8]([C:11](=[O:16])[C:12]([F:15])([F:14])[F:13])[CH2:9][CH2:10][C:4]=2[C:3]=1[NH:37][CH2:36][C:35]1[CH:38]=[CH:39][C:32]([C:30](=[O:31])[CH2:29][CH:28]([CH3:27])[CH3:40])=[CH:33][CH:34]=1

Participants

3

Reactant 2

HCID 28343695HCID 28343695, compoundHCID 574477477-Chloro-3-(2,2,2-trifluoroacetyl)-6-trifluoromethylsulfonyloxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Product 1

HCID 58495679HCID 58495679, compoundYield 45%

Procedure

Use a method similar to the General Procedure 1-3, using 7-chloro-3-(2,2,2-trifluoroacetyl)-6-trifluoromethanesulfonyloxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine (175 mg, 0.42 mmol) and 4-(3-methyl-butyryl)-benzylamine (160 mg, 0.8 mmol) to obtain the title compound as a yellow syrup (85 mg, 45%). MS (ES+) m/z: 467 (M+H)+.

Sources & evidence

ORD record
ord-ee37b6d525b64089b3343a67d4bc3f01
Source dataset
uspto-grants-2014_03
Patent number
US08680091B2

Reaction notes

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