Hydrochloric Acid → HCID 58495591, compound

HRID 1191044Notes

Reaction equation

HRID 1191044 reaction equation
C(OC([NH:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][C:17](=[O:23])[N:18]2[CH2:22][CH2:21][CH2:20][CH2:19]2)=[CH:12][CH:11]=1)=O)(C)(C)C.Cl.O1CCOCC1>C(Cl)Cl>[O:23]=[C:17]([N:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1)[CH2:16][C:13]1[CH:14]=[CH:15][C:10]([CH2:9][NH2:8])=[CH:11][CH:12]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 58495568HCID 58495568, compound

Product 1

HCID 58495591HCID 58495591, compoundYield 102.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Dissolve N-(tert-butoxycarbonyl)-4-(2-oxo-2-pyrrolidin-1-yl-ethyl)-benzylamine (267 mg, 0.8 mmol) in DCM (4 mL). Add 4M hydrogen chloride in dioxane (2 mL, 8 mmol) and stir at room temperature for 1 h. Concentrate in vacuo and elute the compound through a SCX column to obtain the title compound (179 mg, 98%). MS (ES+) m/z: 219 (M+H)+.

Workup

  1. concentrationConcentrate in vacuo
  2. washelute the compound through a SCX column

Sources & evidence

ORD record
ord-ba2c097394724b80bfa9af2a83515f8c
Source dataset
uspto-grants-2014_03
Patent number
US08680091B2

Reaction notes

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