HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[(3,3-Dimethylbutyl-carbamoyl)-methyl]-benzonitrile → 4-[(3,3-Dimethylbutyl-carbamoyl)-methyl]-benzylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[(3,3-Dimethylbutyl-carbamoyl)-methyl]-benzonitrile | HCID 58495664 | — |
| Catalyst | Hydrochloric Acid | HCID 313 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-[(3,3-Dimethylbutyl-carbamoyl)-methyl]-benzylamine | HCID 58495531 | 107.4% |
Reaction Steps
Bubble nitrogen into a solution of 4-[(3,3-dimethylbutyl-carbamoyl)-methyl]-benzonitrile (240 mg, 0.9 mmol) in methanol (20 mL) with 3 drops of concentrated HCl for 10 min. Add 10% Pd/C (Degussa type E101, 48 mg) and submit the mixture to hydrogenation at atmospheric pressure overnight. Filter the catalyst over Celite® and concentrate the filtrate in vacuo. Elute the compound through a SCX column to obtain the title compound (240 mg, 98%). MS (ES+) m/z: 249 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08680091B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-872a73bd2bc24f7db280d50b8e9966a5 |
| Source note | uspto-grants-2014_03 |