反应详情

Bubble nitrogen into a solution of 4-[(3,3-dimethylbutyl-carbamoyl)-methyl]-benzonitrile (240 mg, 0.9 mmol) in methanol (20 mL) with 3 drops of concentrated HCl for 10 min. Add 10% Pd/C (Degussa type E101, 48 mg) and submit the mixture to hydrogenation at atmospheric pressure overnight. Filter the catalyst over Celite® and concentrate the filtrate in vacuo. Elute the compound through a SCX column to obtain the title compound (240 mg, 98%). MS (ES+) m/z: 249 (M+H)+.

1. customat atmospheric pressure overnight
2. filtrationFilter the catalyst over Celite®
3. concentrationconcentrate the filtrate in vacuo
4. washElute the compound through a SCX column