反应详情

Bubble nitrogen into a solution of 6-(3,3-dimethyl-2-oxo-butoxy)-pyridine-3-carbonitrile (400 mg, 1.8 mmol) in methanol (36 mL) with 3 drops of concentrated HCl for 10 min. Add 10% Pd/C (Degussa type E101, 80 mg) and submit the mixture to hydrogenation at atmospheric pressure overnight. Filter the reaction mixture over Celite®. Concentrate the filtrate in vacuo and purify by SCX chromatography to obtain the title compound (223 mg, 55%). MS (ES+) m/z: 223 (M+H)+.

1. customat atmospheric pressure overnight
2. filtrationFilter the reaction mixture over Celite®
3. concentrationConcentrate the filtrate in vacuo
4. custompurify by SCX chromatography