Ethanamine, 2,2,2-trifluoro- → HCID 58495575, compound

HRID 1191074Notes

Reaction equation

HRID 1191074 reaction equation
[F:1][C:2]([F:6])([F:5])[CH2:3][NH2:4].[C:7]([N:15]=[C:16]=[S:17])(=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>C(Cl)(Cl)Cl>[C:7]([NH:15][C:16]([NH:4][CH2:3][C:2]([F:6])([F:5])[F:1])=[S:17])(=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 9773Ethanamine, 2,2,2-trifluoro-HCID 68284Benzoyl isothiocyanate

Product 1

HCID 58495575HCID 58495575, compoundYield 95.3%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

Dissolve trifluoroethylamine (2.2 g, 22 mmol) in chloroform (20 mL) and add the solution to a mixture of benzoyl isothiocyanate (3.5 g, 22 mmol) in chloroform (20 mL) at room temperature. Stir the mixture in a sealed flask for 16 h at room temperature. Concentrate the mixture in vacuo to obtain the desired intermediate as a solid (5.5 g, 95%). MS (ES+) m/z: 263 (M+H)+.

Workup

  1. additionadd the solution
  2. concentrationConcentrate the mixture in vacuo

Sources & evidence

ORD record
ord-3e9c2283b2e24c9095854aa0f24a1371
Source dataset
uspto-grants-2014_03
Patent number
US08680091B2

Reaction notes

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