Succinic Acid → HCID 67465071, compound

HRID 1191129Notes

Reaction equation

HRID 1191129 reaction equation
[Cl:1][C:2]1[CH:12]=[CH:11][C:5]2[CH2:6][CH2:7][NH:8][CH2:9][CH2:10][C:4]=2[C:3]=1[NH:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][N:22]([CH:24]([CH3:26])[CH3:25])[CH3:23])=[CH:17][CH:16]=1.[C:27]([OH:34])(=[O:33])[CH2:28][CH2:29][C:30]([OH:32])=[O:31]>CO>[C:27]([OH:34])(=[O:33])[CH2:28][CH2:29][C:30]([OH:32])=[O:31].[Cl:1][C:2]1[CH:12]=[CH:11][C:5]2[CH2:6][CH2:7][NH:8][CH2:9][CH2:10][C:4]=2[C:3]=1[NH:13][CH2:14][C:15]1[CH:16]=[CH:17][C:18]([CH2:21][N:22]([CH:24]([CH3:26])[CH3:25])[CH3:23])=[CH:19][CH:20]=1

Participants

4

Reactant 2

HCID 1110Succinic AcidHCID 58495446HCID 58495446, compound

Product 1

HCID 67465071HCID 67465071, compoundYield 105.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Dissolve 7-chloro-6-{4-[(N-methyl-iso-propylamino)-methyl]-benzylamino}-2,3,4,5-tetrahydro-1H-benzo[d]azepine (250 mg, 0.67 mmol) in methanol and add succinic acid (75 mg, 0.63 mmol). Stir the mixture until homogeneous. Concentrate the mixture in vacuo, dissolve in water, and freeze dry the solution to obtain the title compound (325 mg, 95%). MS (APCI+) m/z: 372 (M+H)+.

Workup

  1. concentrationConcentrate the mixture in vacuo
  2. dissolutiondissolve in water
  3. customfreeze dry the solution

Sources & evidence

ORD record
ord-6c3320b0b1d64bb6a66a4e2557729f36
Source dataset
uspto-grants-2014_03
Patent number
US08680091B2

Reaction notes

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