Succinic Acid → HCID 67463174, compound

HRID 1191142Notes

Reaction equation

HRID 1191142 reaction equation
[Cl:1][C:2]1[CH:12]=[CH:11][C:5]2[CH2:6][CH2:7][NH:8][CH2:9][CH2:10][C:4]=2[C:3]=1[NH:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][S:22]([CH2:25][C:26]([CH3:29])([CH3:28])[CH3:27])(=[O:24])=[O:23])=[CH:17][CH:16]=1.[C:30]([OH:37])(=[O:36])[CH2:31][CH2:32][C:33]([OH:35])=[O:34]>CO>[C:30]([OH:37])(=[O:36])[CH2:31][CH2:32][C:33]([OH:35])=[O:34].[Cl:1][C:2]1[CH:12]=[CH:11][C:5]2[CH2:6][CH2:7][NH:8][CH2:9][CH2:10][C:4]=2[C:3]=1[NH:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][S:22]([CH2:25][C:26]([CH3:29])([CH3:28])[CH3:27])(=[O:24])=[O:23])=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 1110Succinic AcidHCID 58495461HCID 58495461, compound

Product 1

HCID 67463174HCID 67463174, compoundYield 94.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Dissolve 7-chloro-6-[4-(2,2-dimethyl-propanesulfonylmethyl)-benzylamino]-2,3,4,5-tetrahydro-1H-benzo[d]azepine (316 mg, 0.726 mmol) in methanol (10 mL) and add succinic acid (86 mg, 0.726 mmol). Stir the mixture for 2 h. Concentrate the mixture in vacuo and dry under high vacuum at 50° C. to obtain the title compound (380 mg, 94%). MS (APCI+) m/z: 435 (M+H)+.

Workup

  1. concentrationConcentrate the mixture in vacuo
  2. customdry under high vacuum at 50° C.

Sources & evidence

ORD record
ord-054abe6054ed4daaa95b223a5760e573
Source dataset
uspto-grants-2014_03
Patent number
US08680091B2

Reaction notes

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