(R)-6-chloro-4-methyl-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-one → (R)-6-Bromo-4-methyl-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-one

HRID 11912Notes

Reaction equation

HRID 11912 reaction equation
ClC1N=C2C(=CC=1)C=C1N2[C@H](C)CNC1=O.C(OC([C:22]1[N:31]([C@H:32]([CH3:42])[CH2:33][NH:34][C:35](OC(C)(C)C)=[O:36])[C:25]2=[N:26][C:27]([Br:30])=[CH:28][CH:29]=[C:24]2[CH:23]=1)=O)C>>[Br:30][C:27]1[N:26]=[C:25]2[C:24](=[CH:29][CH:28]=1)[CH:23]=[C:22]1[N:31]2[C@H:32]([CH3:42])[CH2:33][NH:34][C:35]1=[O:36]

Participants

3

Reactant 2

HCID 86590110(R)-6-chloro-4-methyl-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-oneHCID 86596358(R)-6-Bromo-1-(2-tert-butoxycarbonylamino-1-methyl-ethyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester

Product 1

HCID 86760226(R)-6-Bromo-4-methyl-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-one

Procedure

This compound was prepared in analogy to Example 1, intermediate b) from (R)-6-bromo-1-(2-tert-butoxycarbonylamino-1-methyl-ethyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester.

Sources & evidence

ORD record
ord-e07af560f18e4cd3afc3bb14e37b2cbe
Source dataset
uspto-grants-2006_08
Patent number
US07098337B2

Reaction notes

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