HCID 86634375, compound → HCID 11848418, compound

HRID 1191276Notes

Reaction equation

HRID 1191276 reaction equation
[N:1]1([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([NH:14][C@H:15]3[CH2:19][CH2:18][N:17]([CH:20]4[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]4)[C@@H:16]3[CH2:26][N:27]=[N+]=[N-])[N:9]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>C(O)C.[C].[Pd]>[NH2:27][CH2:26][C@@H:16]1[C@@H:15]([NH:14][C:10]2[N:9]=[C:8]([N:1]3[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]3)[CH:13]=[CH:12][N:11]=2)[CH2:19][CH2:18][N:17]1[CH:20]1[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]1

Participants

4

Reactant 1

HCID 86634375HCID 86634375, compound

Product 1

HCID 11848418HCID 11848418, compoundYield 99.3%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

In a solution of the compound 9 (125 mg) in ethanol (4 mL), 10% palladium carbon (wet, 112 mg) was added under an argon atmosphere. The reaction mixture was stirred under a hydrogen atmosphere at room temperature for 30 minutes. The reaction mixture was filtered with Celite (trade name) and the filtrate was concentrated and obtained the title compound (116 mg) having the following physical properties.

Workup

  1. filtrationThe reaction mixture was filtered with Celite (trade name)
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-3cbfe8979af6404491aa12d0b3154938
Source dataset
uspto-grants-2014_03
Patent number
US08680092B2

Reaction notes

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