1,4-Dioxane hydrochloride → HCID 86634378, compound

HRID 1191280Notes

Reaction equation

HRID 1191280 reaction equation
[N:1]([CH2:4][CH2:5][CH:6]1[CH:11]([NH:12]C(OC(C)(C)C)=O)[CH2:10][CH2:9][CH2:8][N:7]1[C:20]([O:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=[O:21])=[N+:2]=[N-:3].[ClH:30].O1CCOCC1>CO>[ClH:30].[NH2:12][CH:11]1[CH2:10][CH2:9][CH2:8][N:7]([C:20]([O:22][CH2:23][C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)=[O:21])[CH:6]1[CH2:5][CH2:4][N:1]=[N+:2]=[N-:3]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 86634377HCID 86634377, compound

Product 1

HCID 86634378HCID 86634378, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The compound 15 (125 mg), methanol (0.5 mL) and 4N hydrogen chloride-dioxane solution (2 mL) were stirred at room temperature for 1 hour. The reaction solution was concentrated and obtained the title compound (118 mg) having the following physical properties.

Workup

  1. concentrationThe reaction solution was concentrated

Sources & evidence

ORD record
ord-588d4fe3a30d455fb5e89c8d77cf20a9
Source dataset
uspto-grants-2014_03
Patent number
US08680092B2

Reaction notes

Loading…